Housed within the Public Health Sciences Division’s Translational Research Program and directed by Dr. Cyrus Ghajar, the Laboratory for the Study of Metastatic Microenvironments (LSM2) seeks to understand some relatively basic questions regarding breast tumor cell dissemination and metastatic relapse. It is now well-established that tumor cells disseminate from the breast to distant organs very early during tumor progression. Even so, a substantial fraction of women will not relapse for several years or even decades after initial treatment. We are interested in figuring out what disseminated tumor cells are doing in the meantime.
Answering these questions holds great promise to halt metastatic disease before it ever has a chance to start, which would result in tremendous gains in patient survival. The answers could also hold the key to understanding some general mysteries in cell and developmental biology such as how tissue size is regulated and how tissue homeostasis is maintained.
We have embarked on some exciting projects to answer the above questions, and utilize a number of different models in our pursuit of the answers. We invite you to look around to learn more about what we do, and please get in touch with any questions.
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Fred Hutchison Cancer Research Center | University of Washington
Institute for Systems Biology | Seattle Biomed