Champoux, James

Faculty Profile

Submitted by Champoux, James on Fri, 10/08/2010 - 6:24pm

First Name:

James

Last Name:

Champoux

Title:

Professor

Primary Institution:

Department/Division:

other

Department/Division:

Microbiology

E-Mail:

champoux@u.washington.edu

Mail/Box #:

357735

Office Location:

J217a

Office Phone:

(206) 543-8574

Lab Website:

http://faculty.washington.edu/champoux/

Research

Research Summary:

The research in Dr. Champoux's laboratory is focused on several projects relating to the enzymology of nucleic acid synthesis and repair. One project is concerned with human DNA topoisomerase I, an enzyme that provides swivels to remove torsional strain during DNA replication, transcription and chromatin assembly. A related study focuses on tyrosyl-DNA phosphodiesterase 1(Tdp1) a repair enzyme that removes topoisomerase I molecules that become covalently trapped on DNA. A second project concerns the mechanism of reverse transcription during retroviral replication. Specific studies look at the roles of RNase H and the importance of displacement synthesis by the polymerase activity of reverse transcriptase in reverse transcription.

Short Research Description:

Topoisomerases and retroviral replication

Areas of Interest:

Microbiology, Infection & Immunity

Molecular Structure & Computational Biology

Keywords:

<p> DNA topoisomerase, DNA replication, DNA repair, tyrosyl-DNA phosphodiesterase, DNA topology, supercoiling, gene expression, cell biology, reverse transcription, RNase H, retroviruses, retrovirology, HIV-1, Moloney murine leukemia virus, transcription, crystal structures, crystallography, enzymology</p>

Publications

PubMed Search Term:

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Champoux, James

Faculty Profile

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