Clark, John

Faculty Profile

First Name: 
John
Last Name: 
Clark
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Title: 
Professor
Primary Institution: 
UW
Department/Division: 
other
Department/Division: 
Biological Structure
Mail/Box #: 

357420 Biostructure

Office Location: 

G-525

Office Phone: 
(206) 685-0950
Research

Research Summary: 

The development of the transparent structure of lens cells is a unique problem in biology that involves symmetry at the molecular, cellular and tissue levels and highly coordinated interactions between proteins and cells. Our most recent work is on the differentiation of lens fiber cells in zebra fish. Separate studies on on the molecular interactions between proteins responsible for development of normal transparent structure and for the loss of transparency in aggregation diseases that include cataract, neurodegeneration and cardiovascular disease.  Overexpression of human amyloid proteins is being conducted to quantify the mechanism(s) of amyloid formation and the impact on cell differentiation and function.

Short Research Description: 
The molecular basis for cell transparency
Areas of Interest: 
Developmental Biology, Stem Cells & Aging
Keywords: 
<p> cell biology, biophysics, biochemistry, developmental biology, molecular biology, lens biology, microscopic structure, vision sciences, molecular chaperones, protein aggregation diseases,aging</p>
Publications


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