We investigate host responses to Gram negative bacterial infections and develop products and tools with application(s) in clinical medicine for diagnosis and therapy. The basic research component focuses on studying innate and adaptive immune responses to bacterial infection, and the mechanism(s) of inflammation and cell death. We uncovered a new biological paradigm, a conserved pathway of pro-inflammatory cell death called pyroptosis, which is evoked by infection and other important pathological insults, such as cancer, heart disease, and stroke. Our lab uses techniques in cellular immunology, bacterial genetics, biochemistry, cell biology and molecular biology.
Copyright © 2003-2014 Molecular & Cellular Biology Program, University of Washington
Fred Hutchison Cancer Research Center | University of Washington
Institute for Systems Biology | Seattle Biomed