Seattle Biomedical Research Institute307 Westlake Ave. N., Suite 500Seattle, WA 98109-5219
With about 30% of the world's population infected and 1.4 million deaths caused each year, Mycobacterium tuberculosis is the world's deadliest bacterium. The Sherman laboratory studies the bacterial and host strategies that underpin this success. We use tools of systems biology such as transcriptomics, ChIP-seq and modeling to define the TB gene regulatory network under physiologically relevant conditions, and use the modeling in turn to produce testable hypotheses about novel regulatory circuits, genes and proteins of TB. This iterative approach allows us continually to test and refine our understanding of TB pathogenesis. In addition, we are always looking to mine systems-level insights to identify and validate novel TB drug targets and to advance new drug candidates.
Copyright © 2003-2014 Molecular & Cellular Biology Program, University of Washington
Fred Hutch | University of Washington
Institute for Systems Biology (ISB)| Center for Infectious Disease Research