Sherman, David

Faculty Profile

First Name: 
David
Last Name: 
Sherman
[field_fname-formatted] [field_lname-formatted]
Title: 
Professor
Primary Institution: 
Seattle BioMed
Department/Division: 
other
Department/Division: 
other
Office Location: 

Seattle Biomedical Research Institute
307 Westlake Ave. N., Suite 500
Seattle, WA 98109-5219

Office Phone: 
206-256-7242
Research

Research Summary: 

With about 30% of the world's population infected and 1.4 million deaths caused each year, Mycobacterium tuberculosis is the world's deadliest bacterium. The Sherman laboratory studies the bacterial and host strategies that underpin this success. We use tools of systems biology such as transcriptomics, ChIP-seq and modeling to define the TB gene regulatory network under physiologically relevant conditions, and use the modeling in turn to produce testable hypotheses about novel regulatory circuits, genes and proteins of TB.  This iterative approach allows us continually to test and refine our understanding of TB pathogenesis.  In addition, we are always looking to mine systems-level insights to identify and validate novel TB drug targets and to advance new drug candidates.

Short Research Description: 
tuberculosis systems biology: virulence and dormancy
Areas of Interest: 
Genetics, Genomics & Evolution
Microbiology, Infection & Immunity
Keywords: 
<p> gene expression, systems biology, pathogenesis, tuberculosis, vaccine, bacterial pathogenesis, dormancy, drug development, gene expression, hypoxia, latency, mycobacteria, transcription, tuberculosis, vaccine, virulence</p>
Publications

Taking Students
Year: 
2015 - 2017

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Student Profile