Wang, Edith

Faculty Profile

First Name: 
Edith
Last Name: 
Wang
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Title: 
Associate Professor
Primary Institution: 
UW
Department/Division: 
other
Department/Division: 
Pharmacology
Mail/Box #: 

357280

Office Location: 

E417 HSB

Office Phone: 
(206) 616-5376
Research

Research Summary: 

 

The major research interest of the Wang lab is the regulation of gene transcription and its role in cell proliferation and human disease. Our studies focus on the function of the general transcription factor complex TFIID and how mutations in its TAF subunits contribute to cancer or other human genetic disorders. The Wang lab uses molecular, biochemical and structural approaches to investigate the normal function of TAFs in gene transcription and how debilitating mutations may contribute to cancer, cognitive impairment, and neurodegeneration. 

Research projects in the lab include: 1) unravelling the dynamic TAF1-TAF7 module of TFIID in cell cycle progression, 2) defining the domains of TAF1 and TAF2 that interface with core promoter DNA and the mechanism that conveys DNA sequence specificity, and 3) investigating the functional consequences of TAF1 and TAF2 mutations that co-segregate with human genetic disorders.

Our long-term goal is to understand how misregulation of gene transcription promotes human disease and to assess the potential of the TAF subunits of TFIID as druggable targets or diagnostic markersfor improving human health.

Short Research Description: 
Transcription Regulation and Human Disorders
Areas of Interest: 
Gene Expression, Cell Cycle & Chromosome Biology
Molecular Structure & Computational Biology
Keywords: 
<p> Transcriptional regulation, cell cycle, gene expression, histone acetyltransferase activity, promoter DNA binding, human genetic disorders</p>
Publications


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