My research investigates the role of vaginal lactobacilli in the prevention and pathogenesis of bacterial vaginosis. To elucidate the effect of vaginal Lactobacillus colonization on the likelihood of developing BV, I am performing an epidemiological analysis on data generated by a longitudinal cohort study on the dynamics of the vaginal microbiota. Additionally, my research examines the extent to which production of antimicrobial substances differs across Lactobacillus species. To do this, I am performing a comparative genomics analysis of vaginal lactobacilli to examine differences in the numbers and kinds of small, antimicrobial peptides encoded. Thesein silico findings will be compared to in vitro antimicrobial activity against bacterial vaginosis-associated bacteria.
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Fred Hutch | University of Washington
Institute for Systems Biology (ISB)| Center for Infectious Disease Research