I am interested in the molecular and cellular basis of plasticity in neural circuits that regulate birdsong. I emphasize a comparative, evolutionary approach to this system, and combine behavioral studies, neuroendocrinology, neuroanatomy, moleclular biology, and signal analysis. I am currently pursuing three major topics of study in the song system. One concerns the physiological and molecular mechanisms, and the behavioral consequences, of seasonal plasticity observed in the morphology, electrophysiology, and gene expression patterns of song regions of the brain. A second topic concerns the recruitment of new neurons to a song nucleus in the cortex of adult birds, studied from the perspective of its physiological regulation and the influence of environmental factors. The third topic relates to the role that kinase signaling cascades play in mediating the neuroprotective effects that steroid hormones have on the song control circuits.
Copyright © 2003-2014 Molecular & Cellular Biology Program, University of Washington
Fred Hutchison Cancer Research Center | University of Washington
Institute for Systems Biology | Seattle Biomed