erinem

Student Profile

Submitted by erinem on Tue, 10/27/2009 - 9:44am

First Name:

Erin

Last Name:

Mulkearns-Hubert

Primary Institution:

FHCRC

Department/Division:

Basic Sciences

Department/Division:

other

MCB Entry Quarter:

Autumn

MCB Entry Year:

2006

E-Mail:

erinem@u.washington.edu

Mail/Box #:

358080/A2-025

Address:

Lab Information

Advisor:

fhjcoope

Lab Location:

A2-111

Lab Phone #:

(206) 667-4465

Research

Research Summary:

I study how cells internalize transmembrane receptors via clathrin-mediated endocytosis. Our lab focuses specifically on one clathrin adaptor, Dab2, which links receptors containing NPxY sequences to clathrin and other components of the endocytic machinery. Using mass spectrometry, I have identified novel Dab2-binding proteins with a role in endocytosis. I characterized the function of the F-BAR protein FCHO2 and the importance of its bond with Dab2. I am currently working to learn more detail about the interaction between Dab2 and FCHO2 and how Dab2 activity is regulated.

Areas of Interest:

Cell Signaling & Cell/Environment Interactions

Genetics, Genomics & Evolution

Molecular Structure & Computational Biology

Publications:

22323290

Academic Information

Rotation Labs:

dgallowa

memerman

fhjcoope

TA/Out Reach

Class/Activity:

Biol 355

Quarter:

Autumn

Year:

2008