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The long-range objective of Dr. Faustman’s research is two-fold: to identify biochemical mechanisms of developmental toxicity and to develop new methods for the evaluation of health risks posed by environmental agents. Major research efforts in the laboratory are currently directed towards metals; primarily methylmercury, arsenic, and cadmium; pesticides, such as organophosphates; and other known carcinogens, mutagens, and teratogens. Both in vitro and in vivo methods have been applied to explore the molecular mechanism of developmental toxicity of these agents.
Dr. Faustman’s efforts in risk assessment include research to integrate results derived from laboratory experiments to develop mechanistically-based toxicokinetic and toxicodynamic models of developmental toxicity. Additionally, Dr. Faustman is involved in the development of new methods applicable to both cancer and noncancer risk assessment. Currently, techniques are being developed to enhance our understanding of the cellular and molecular factors involved in normal and toxicant-perturbed neurodevelopment. Methodologies include genomic, metagenomic, and proteomic analyses for assessment of molecular impact of neurotoxicants.
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Fred Hutch | University of Washington
Institute for Systems Biology (ISB)| Center for Infectious Disease Research