faustman

Faculty Profile

First Name: 
Elaine
Last Name: 
Faustman
[field_fname-formatted] [field_lname-formatted]
Title: 
Professor
Primary Institution: 
UW
Department/Division: 
other
Department/Division: 
Environmental Health
Mail/Box #: 

354695

Office Location: 

4225 Roosevelt Way NE, Suite 100

Office Phone: 
(206) 685-2269
Research

Research Summary: 

The long-range objective of Dr. Faustman's research is two-fold: to identify biochemical mechanisms of developmental toxicity and to develop new methods for the evaluation of health risks posed by environmental agents. Major research efforts in the laboratory are currently directed towards metals, primarily methylmercury, arsenic, cadmium, pesticides, such as organophosphates, benomyl and N-Nitroso compounds, and other known carcinogens, mutagens and teratogens. In vitro experiments are performed using primary rat embryo cell cultures for CNS and limb tissues, and embryonal carcinoma cells to investigate mechanisms of developmental toxicity of these agents. Embryonal fibroblasts are also isolated from transgenic animals and used to evaluate the role of specific gene pathways in toxicant induced developmental effects. Dr. Faustman's efforts in risk assessment include an effort to combine results derived from laboratory experiments to develop mechanistically-based toxicokinetic and toxicodynamic models of developmental toxicity. Additionally, Dr. Faustman is involved in the development of new methods applicable to both cancer and non-cancer risk assessment. Currently, techniques are being developed to enhance our understanding of the cellular and molecular factors involved in normal and toxicant-perturbed neurodevelopment. Methodologies include microarray genomic and proteomic analyses for assessment of molecular impact of neurotoxicants of changes at the level of protein expression and function. Please contact the researcher listed with the individual project for more information on research opportunities.

Short Research Description: 
environmental toxicity
Areas of Interest: 
Cell Signaling & Cell/Environment Interactions
Keywords: 
<p> cell culture, etiology, pregnancy, public health, toxicology, biotransformation, cell culture, DNA, embryo culture, enzyme systems, etiology, pregnancy, public health, toxicology</p>
Publications