Cooper, Jonathan

Faculty Profile

First Name: 
Jonathan
Last Name: 
Cooper
[field_fname-formatted] [field_lname-formatted]
Primary Institution: 
FHCRC
Department/Division: 
Basic Sciences
Department/Division: 
other
E-Mail: 
Mail/Box #: 

A2-025

Office Location: 

A2-105 FHCRC

Office Phone: 
(206) 667-4454
Research

Research Summary: 

We are interested in the molecular mechanisms, specifically tyrosine phosphorylation and ubiquitylation, that regulate cell morphology and migration during normal development, and how these events are deregulated in cancer. We make extensive use of in vivo studies using mutant mice as well as cell and tissue culture systems. Genetic studies, guided by biochemistry, have uncovered a signaling pathway involving the Src tyrosine kinase, Dab1 adaptor and Cul5 E3 ligase that regulates neuron migrations during brain development. Some components of the pathway also regulate malignant transformation and migration of cells in culture.

Short Research Description: 
Regulation of neuron migration and cancer
Areas of Interest: 
Cell Signaling & Cell/Environment Interactions
Developmental Biology, Stem Cells & Aging
Keywords: 
<p> phosphoproteins, protein traffic, receptors, neurobiology, cell migration, integrin signaling, cell adhesion, tyrosine kinases, signal transduction, oncogenes, phosphotyrosine</p>
Publications


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