Hamerman, Jessica

Faculty Profile

First Name: 
Jessica
Last Name: 
Hamerman
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Title: 
Associate Professor
Primary Institution: 
Benaroya Research Institute
Department/Division: 
other
Department/Division: 
other
Mail/Box #: 

357650

Office Location: 

1201 9th Ave., Seattle, WA 98101

Office Phone: 
(206) 287-1077
Research

Research Summary: 

Research in our laboratory focuses on the regulation of the innate immune response to pathogens with an emphasis on macrophages and dendritic cells. Macrophages and dendritic cells are distributed throughout the body where they are poised to detect pathogens and to subsequently alert the immune system to the presence of infection through the production of inflammatory mediators. Macrophages and dendritic cells recognize pathogens by a variety of cell surface and intracellular receptors termed pattern recognition receptors, including the family of Toll-like receptors (TLR). We study how signaling through pattern recognition receptors results in the appropriate inflammatory response by macrophages and dendritic cells. We are particularly interested in proteins that inhibit signaling through pattern recognition receptors, providing an essential brake to the inflammatory response. These studies will not only help elucidate how inflammatory cytokine production is regulated during infection, but will potentially give insights in how to manipulate the innate immune system to achieve more efficient elimination of pathogens and to regulate the inflammatory response during autoimmune disease, such as rheumatoid arthritis and systemic lupus erythematosus.

Short Research Description: 
Regulation of innate immune response
Areas of Interest: 
Microbiology, Infection & Immunity
Keywords: 
<p> bacteria, cell biology, dendritic cells, immunobiology, immunology, infectious diseases, infection, inflammation, innate immunity, macrophages, microbiology, viruses</p>
Publications


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