Ruohola-Baker, Hannele

Faculty Profile

First Name: 
Hannele
Last Name: 
Ruohola-Baker
[field_fname-formatted] [field_lname-formatted]
Title: 
Professor
Primary Institution: 
UW
Department/Division: 
other
Department/Division: 
Biochemistry
Mail/Box #: 

358056

Office Location: 

UW Medicine South Lake Union, Rm. S 581
850 Republican Street
Seattle, WA 98109

Office Phone: 
(206) 543-8468
Alternate Phone: 
(206) 310-7419
Research

Research Summary: 

My laboratory studies the molecules and cellular properties that are required for stem cell states and their differentiation capacity, both in normal and pathological situations. During the recent years we have shown that microRNAs and HIF pathways play key roles in regulating adult and embryonic stem cell self-renewal in model organisms as well as in hESC and iPSC. The laboratory presently works on three questions: 1) what are the metabolic determinants of stem cells, 2) what are the key microRNAs that induce cardiomyocyte maturation and 3) what is the molecular mechanism of stem cell protection against apoptosis.

Short Research Description: 
stem cells in development and disease, muscular dystrophy
Areas of Interest: 
Cancer Biology
Cell Signaling & Cell/Environment Interactions
Developmental Biology, Stem Cells & Aging
Gene Expression, Cell Cycle & Chromosome Biology
Keywords: 
<p> genetics, cancer, cell biology, cell differentiation, cell growth, cell kinetics, cell-cell interactions, cytokinesis, cytoskeleton, developmental biology, gene, gene expression, gene regulation, genetics, growth factor receptors, growth factors, ion channels, membrane transport, mitosis, molecular structure, mutagenesis, mutation, nervous system, neurobiology, oncology, reproductive biology, specific cell types, stem cells, tumor biology</p>
Publications

Taking Students
Year: 
2015 - 2016

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