hhorton

Dr. Horton’s research focuses on understanding the mechanisms that enable some individuals to control chronic viral infections, like HIV-1. Uncovering this new knowledge could lead to novel therapeutic interventions and more rational design of prophylactic or therapeutic vaccines components.

Several key questions drive the research in the Horton Lab: Why are some viral infections cleared while others persist? Can the knowledge gained from rare individuals who can control chronic viral infections be used to design more efficacious vaccines? Can ineffective immune responses induced in the majority of individuals with chronic viral infection be manipulated to possess more effective phenotypes? Are there age-specific differences in anti-viral immunity that could explain why HIV-infected infants have poorer clinical outcomes than HIV-infected adults?