Hille, Bertil

Faculty Profile

First Name: 
Bertil
Last Name: 
Hille
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Title: 
Professor
Primary Institution: 
UW
Department/Division: 
other
Department/Division: 
Physiology & Biophysics
E-Mail: 
Mail/Box #: 

357290

Office Location: 

H-310G Magnuson Health Sciences Center

Office Phone: 
(206) 543-8639
Research

Research Summary: 

We are interested in cell signaling by ion channels, neurotransmitters and hormones acting through G-protein coupled receptors and intracellular calcium. Our overall goal is to define every step and the molecular mechanisms underlying physiologically interesting regulation of ion channels and membrane proteins in single cells, with emphasis on events that occur in time scales of microseconds to seconds.

Our work is biophysical and seeks quantitative explanation and modeling.  The cell membrane, cytoplasm and intracellular organelles form a rapidly interacting signaling network. We study single neurons, endocrine cells, epithelial cells, and cell lines using techniques associated with the patch clamp: voltage clamp, membrane capacitance, optical imaging, TIRF, FRET, and photometry of fluorescent dyes. We have analysed G-protein coupled modulation of neuronal Ca channels and K channels, exocytosis and secretion from vesicles, dynamics of intraorganellar calcium, and signaling and dynamics of metabolism of membrane phosphoinositide lipids.

Short Research Description: 
Signaling, ion channels, G-protein coupled receptors
Areas of Interest: 
Neuroscience
Keywords: 
<p> Biophysics, Calcium signaling, Cell Biology, Cell Physiology, Electrophysiology, Endocrine System, Endocrinology, FRET, GPCRs, G proteins, Hormones, Ion Channels, Membrane Transport, Neurons, Neurotransmitters, Patch Clamp, Physiology, Receptors, PIP<sub>2</sub>, Signaling, Cell signaling</p>
Publications


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