Horwitz, Marshall

Faculty Profile

First Name: 
Marshall
Last Name: 
Horwitz
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Title: 
Professor
Primary Institution: 
UW
Department/Division: 
other
Department/Division: 
Pathology
E-Mail: 
Mail/Box #: 

358056

Office Location: 

Institute for Stem Cell & Regenerative Medicine (ISCRM)
815 Mercer St., Room N435
Seattle, WA 98109-4714

Office Phone: 
(206) 616-4566
Alternate Phone: 
(206) 616-4567
Research

Research Summary: 

Dr. Horwitz's research interests are focused on cancers of the blood and bone marrow failure syndromes. His laboratory employs genetic linkage analysis and positional candidate cloning approaches to map and identify genes responsible for familial predisposition to leukemia, lymphoma, and bone marrow failure syndromes. His laboratory has found genes responsible for human cyclic neutropenia, canine cyclic hematopoiesis, and severe congenital neutropenia (Kostmann syndrome). The lab employs molecular biology and biochemical approaches aimed at elucidating mechanisms of cellular differentiation during hematopoiesis. More recently, his laboratory has embarked on a new approach for constructing cell fate maps by inferring the order in which somatic mutations accumulate during the course of development.

Short Research Description: 
hereditary blood cancers and tumor clonality
Areas of Interest: 
Developmental Biology, Stem Cells & Aging
Genetics, Genomics & Evolution
Keywords: 
<p> hematopoiesis, neutropenia, leukemia, cancer, molecular biology, molecular genetics, positional cloning, linkage analysis, bone marrow, geneexpression, proteases, granulopoiesis, human genetics, medical genetics, blood, neutrophils, platelets, transgenic, gene targeting, development, fate maps</p>
Publications

Taking Students
Year: 
2013 - 2014

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