Horwitz, Marshall

Dr. Horwitz's research interests are focused on cancers of the blood and bone marrow failure syndromes. His laboratory employs genetic linkage analysis and positional candidate cloning approaches to map and identify genes responsible for familial predisposition to leukemia, lymphoma, and bone marrow failure syndromes. His laboratory has found genes responsible for human cyclic neutropenia, canine cyclic hematopoiesis, and severe congenital neutropenia (Kostmann syndrome). The lab employs molecular biology and biochemical approaches aimed at elucidating mechanisms of cellular differentiation during hematopoiesis. More recently, his laboratory has embarked on a new approach for constructing cell fate maps by inferring the order in which somatic mutations accumulate during the course of development.