Malik, Harmit

Faculty Profile

First Name: 
Harmit
Last Name: 
Malik
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Title: 
Member
Primary Institution: 
FHCRC
Department/Division: 
Basic Sciences
Department/Division: 
other
E-Mail: 
Mail/Box #: 

A2-025

Office Location: 

Fred Hutchinson Cancer Research Center
1100 Fairview Avenue N, A2-205
Mailstop A2-025
Seattle WA 98109.

Office Phone: 
(206) 667-5204
Research

Research Summary: 

Our genomes are a tenuous conglomerate of different genetic entities, each trying to maximize their own evolutionary success, often at great cost to their genomic neighbors. As expected, this conflict can create problems for the host organism. My lab is interested in evolutionary studies of genetic conflict to gain insight into their mechanisms and consequences. We study genetic conflicts primarily in three systems: Drosophila, primates and yeast. While there are a number of investigative projects that are going on at any given time in the lab, our focus is on three conflicts in particular:

* centromeres

* innate and intrinsic immunity against viruses in primates

* mobile genetic elements in Drosophila.

Short Research Description: 
evolutionary studies of genetic conflict
Areas of Interest: 
Gene Expression, Cell Cycle & Chromosome Biology
Genetics, Genomics & Evolution
Microbiology, Infection & Immunity
Keywords: 
<p> Mobile genetic elements, rapidly evolving proteins in yeast and Drosophila, Phylogenomics, sequence analysis, evolution, speciation, satellite DNA, centromeres</p>
Publications

Taking Students
Year: 
2013 - 2014

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