Lingappa, Jaisri

Faculty Profile

First Name: 
Jaisri
Last Name: 
Lingappa
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Title: 
Associate Professor
Primary Institution: 
UW
Department/Division: 
other
Department/Division: 
Global Health
Mail/Box #: 

358116

Office Location: 

1616 Eastlake Ave. E., Suite 300/305, Seattle, WA 98102

Office Phone: 
(206) 616-9305
Research

Research Summary: 

The Lingappa lab studies viral host interactions involved in assembly of human immunodeficiency virus type 1 (HIV-1) and other viruses.  Previously, our group showed that immature HIV-1 capsid assembly in cells occurs through a pathway of assembly intermediates, and is facilitated by the catalytic activity of the host enzymes ABCE1 and DDX6.  Our recent studies show that ABCE1 binds directly to HIV Gag through an ancient binding site that is present even in the Ty3 retrotransposon Gag protein.  One current direction in the lab involves studying the evolution, structure, and function of the ABCE1-Gag binding site.  A second direction addresses how polymorphisms that arise in Gag in vivo can enhance ABCE1-Gag binding, thereby accelerating the kinetics of this assembly pathway and increasing virus particle production.  These studies test the hypothesis that altering viral-host interactions during assembly could impact viral set point and viral load, and therefore have important implications for understanding HIV-1 pathogenesis.  A third direction involves understanding how the HIV-1 genome is packaged by assembly intermediates during capsid assembly in cells.  Our studies have also led to development of novel antiviral compounds that inhibit virus replication by acting on the capsid assembly pathway.

Short Research Description: 
viral-host interactions in capsid assembly
Areas of Interest: 
Cell Signaling & Cell/Environment Interactions
Microbiology, Infection & Immunity
Keywords: 
<p> Pathogenesis, Virology, Cell Biology, Biochemistry</p>
Publications

Taking Students
Year: 
2013 - 2014

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