J-279A Health Sciences
My lab is primarily focused on understanding the role of defensins in viral pathogenesis. Defensins are a class of antimicrobial peptides with broadly acting antibacterial activity; however, their role in antiviral immunity, particularly for nonenveloped viruses, is less well understood. Using a variety of approaches from virology, cell biology, biochemistry, structural biology, and genetics, our work is focused on understanding the interaction of defensins with pathogenic viruses, including adenovirus, HPV, and rotavirus, in molecular detail. We are also interested in using animal models of viral diseases to understand the role of defensins in antiviral immunity in vivo and are using exciting new 3D intestinal organoid technology to model enteric infection in vitro.
Copyright © 2003-2014 Molecular & Cellular Biology Program, University of Washington
Fred Hutchison Cancer Research Center | University of Washington
Institute for Systems Biology | Seattle Biomed