J-279A Health Sciences
My lab is primarily focused on understanding the role of defensins in antiviral immunity. Defensins are a class of antimicrobial peptides with broadly acting antibacterial activity; however, their role in antiviral immunity, particularly for nonenveloped viruses, is less well understood. Using a variety of approaches from virology, cell biology, biochemistry, structural biology, and genetics, our work is focused on understanding the interaction of defensins with human adenovirus in molecular detail. We are also interested in using animal models of viral diseases to understand the role of defensins in antiviral immunity in vivo. Finally, through comparative studies with other nonenveloped viruses such as human papillomavirus and adeno-associated virus, we will determine general principals of defensin-mediated neutralization of nonenveloped virus infection.
Copyright © 2003-2013 Molecular & Cellular Biology Program, University of Washington
Fred Hutchison Cancer Research Center | University of Washington
Institute for Systems Biology | Seattle Biomed