Room 358a, Rosen Bldg., 960 Republican St., Seattle, WA 98109
The Mullins lab uses the techniques of molecular, computational and virus biology to provide basic insights into the HIV-human host relationship in an effort to help stop the AIDS pandemic. They use a variety of techniques to understand the implications of HIV's extraordinary genetic diversity for the pathogenesis of AIDS, with the intention of applying this information to the development of more effective therapies and vaccines. These techniques include virology, molecular biological and statistical analysis of nucleotide sequences. Current projects include: studies of adaptations of the virus and cellular immune responses during early infection; events leading to loss of virological control after prolonged periods of asymptomatic infection; identification and characterization of reservoirs of latent and continuing virus production during antiretroviral therapy (ART); mechansims of persistance of HIV reservoirs during ART; host gene expression associated with resistance to HIV infection; and tests of the concept of using conserved elements of the viral proteome as prophylactic and therapeutic vaccines.
Copyright © 2003-2014 Molecular & Cellular Biology Program, University of Washington
Fred Hutch | University of Washington
Institute for Systems Biology (ISB)| Center for Infectious Disease Research