My lab is broadly interested in the information and organization principles of signaling –protein networks that respond to a changing environment and diverse cellular needs to make real-time decisions–.
The broad questions we are trying to answer are: what are the signaling components, how are they connected, how signaling networks orchestrate the communication between cellular sensors and effectors to direct cellular functions, how these networks parse information differently in different cell types, and how signaling proteins go out of control in disease.
To address these questions we develop and apply proteomic technologies that provide a systems-level view of signaling. Our long-term goal is to understand the wiring diagram of a cell at such resolution that we can predict and control cellular output, encompassing molecules, shapes, and functions.
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Fred Hutch | University of Washington
Institute for Systems Biology (ISB)| Center for Infectious Disease Research