Kaeberlein, Matthew

Faculty Profile

First Name: 
Matthew
Last Name: 
Kaeberlein
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Title: 
Associate Professor
Primary Institution: 
UW
Department/Division: 
other
Department/Division: 
Pathology
Mail/Box #: 

357470

Office Location: 

D-514A Health Sciences Center

Office Phone: 
(206) 221-3745
Research

Research Summary: 

We believe that an effective approach toward developing therapies for age-associated disease is to focus on evolutionarily conserved longevity factors. The rationale behind this approach is that if a particular gene functions to regulate aging in evolutionarily divergent model organisms, then there is a good chance that it will have a similar function in humans. Once these genes are identified, it will be possible to develop drugs specifically targeting the protein of interest. If these drugs increase life span or delay the onset of age-associated disease in mice, they will be good candidates for human clinical trials. We are vigorously pursuing the identification and characterization of evolutionarily conserved determinants of longevity using three model organisms: the budding yeast, C. elegans, and mice. Current projects in the lab include aging-related studies of dietary restriction, the hypoxic response, mTOR signaling, and mitochondrial disease.

Short Research Description: 
Molecular mechanisms of aging
Areas of Interest: 
Cell Signaling & Cell/Environment Interactions
Developmental Biology, Stem Cells & Aging
Genetics, Genomics & Evolution
Neuroscience
Keywords: 
<p> ageing, genetics, yeast, worm, Caenorhabditis elegans, Saccharomyces cerevisiae, mice, TOR, Sir2, longevity, resveratrol, rapaycin, unfolded protein response, translation, proteotoxicity, dietary restriction, carlorie restriction, caloric restriction, diet, obesity, polyglutamine, amyloid beta, Huntington&#39;s disease, Alzheimer&#39;s disease, molecular biology, hypoxic response, Leigh Syndrome</p>
Publications


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