Kimelman, David

Faculty Profile

First Name: 
David
Last Name: 
Kimelman
[field_fname-formatted] [field_lname-formatted]
Title: 
Professor
Primary Institution: 
UW
Department/Division: 
other
Department/Division: 
Biochemistry
Mail/Box #: 

357350

Office Location: 

HSB J533A

Office Phone: 
(206) 543-5730
Research

Research Summary: 

The laboratory works on the early development of the zebrafish embryo. We work to understand how intercellular signals (particularly Wnts, Fgfs and Bmps) regulate the activation of downstream target genes in order to convert progenitors (stem-like cells) into differentiated cells during embryogenesis. We use transgenic zebrafish expressing heat-shock inducible activators and inhibitors of these pathways in order to examine how this process works in a living embryo. A second part of our work examines the morphogenetic changes (cell movements) that occur in zebrafish embryos, and the proteins regulating the morphogenesis, particularly a large scaffolding protein called Gravin that brings together downstream regulators. For more on both topics, please see the lab web page.

Short Research Description: 
Early embryonic zebrafish development
Areas of Interest: 
Cell Signaling & Cell/Environment Interactions
Developmental Biology, Stem Cells & Aging
Keywords: 
<p> biochemistry, biology, developmental or evolutionary, embryology, gene expression, cell biology, cell-cell interactions, developmental biology, embryology, gene, gene expression, gene regulation, growth factor receptors, growth factors, system development</p>

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