Stuart, Kenneth

Faculty Profile

First Name: 
Last Name: 
[field_fname-formatted] [field_lname-formatted]
Primary Institution: 
Seattle BioMed
Mail/Box #: 


Office Location: 

Seattle Biomedical Research Institute
307 Westlake Ave. N., Suite 500
Seattle, WA 98109-5219

Office Phone: 
(206) 256-7316
Alternate Phone: 
(206) 256-7302

Research Summary: 

The Stuart lab is focused on Trypanosomatid pathogens: Trypanosoma brucei, Trypanosoma cruzi, and Leishmania species. One major focus is on the process of, the molecular machinery for, and the physiological significance of RNA editing, and the potential for developing drugs directed at this process or its physiological role. Dr. Stuart determined the general mechanism of editing, identified many components of the editosome and the functions and interactions of many of these components. His lab is exploring editosome functional structure, steps in the editing process, and effects on parasite physiology upon disruption of editing. A second focus of the Stuart lab is functional genomics. He led the formation of international genome projects that sequenced and compared Trypanosome and Leishmania genomes in close collaboration with Peter Myler, Ph.D. His current projects are building on these sequencing efforts and include a mitochondrial proteomic project that is designed to identify the functions of all proteins in this organelle for the purpose of developing drugs that are needed for several diseases caused by this group of pathogens.

Short Research Description: 
Protozoan pathogens
Areas of Interest: 
Genetics, Genomics & Evolution
Microbiology, Infection & Immunity
<p> <span style="line-height: 115%; font-family: &quot;calibri&quot;,&quot;sans-serif&quot;; font-size: 11pt; mso-ascii-theme-font: minor-latin; mso-fareast-font-family: calibri; mso-fareast-theme-font: minor-latin; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: &quot;times new roman&quot;; mso-bidi-theme-font: minor-bidi; mso-ansi-language: en-us; mso-fareast-language: en-us; mso-bidi-language: ar-sa;"><font color="#000000">trypanosomes, Leishmania, protozoan pathogens, RNA processing, RNA editing, gene function, genome sequencing, expression profiling, proteomics, molecular biology, DNA sequencing, genes, molecular complexes, drugs, diagnostics, vaccines, mitochondrion</font></span></p>

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