Seattle Biomedical Research Institute307 Westlake Ave. N., Suite 500Seattle, WA 98109-5219
The Stuart lab is focused on Trypanosomatid pathogens: Trypanosoma brucei, Trypanosoma cruzi, and Leishmania species. One major focus is on the process of, the molecular machinery for, and the physiological significance of RNA editing, and the potential for developing drugs directed at this process or its physiological role. Dr. Stuart determined the general mechanism of editing, identified many components of the editosome and the functions and interactions of many of these components. His lab is exploring editosome functional structure, steps in the editing process, and effects on parasite physiology upon disruption of editing. A second focus of the Stuart lab is functional genomics. He led the formation of international genome projects that sequenced and compared Trypanosome and Leishmania genomes in close collaboration with Peter Myler, Ph.D. His current projects are building on these sequencing efforts and include a mitochondrial proteomic project that is designed to identify the functions of all proteins in this organelle for the purpose of developing drugs that are needed for several diseases caused by this group of pathogens.
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Fred Hutchison Cancer Research Center | University of Washington
Institute for Systems Biology | Seattle Biomed