Laflamme, Michael

My laboratory is interested in cardiac applications for human embryonic stem cells (hESCs). Particular areas of emphasis include the use of hESC-derived cardiomyocytes to achieve cardiac repair in rodent infarct models and testing the ability of such cells to undergo appropriate electromechanical integration with host myocardium. We also have ongoing efforts to control the cardiac subtype specialization of hESC-derived cardiomyocytes, that is, to identify pharmacologic and genetic approaches to generate specific ventricular-, atrial, and nodal/pacemaker-like cells from hESCs.