Lampe, Paul

Faculty Profile

First Name: 
Paul
Last Name: 
Lampe
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Primary Institution: 
FHCRC
Department/Division: 
Human Biology
Department/Division: 
other
E-Mail: 
Mail/Box #: 

M5-C800

Office Location: 

M5-C801

Office Phone: 
(206) 667-4123
Alternate Phone: 
(206) 667-5408
Research

Research Summary: 

The Lampe laboratory investigates the control of cell growth both at the cell biological/ mechanistic level and through cancer biomarker discovery. We study the cell biology connecting gap junctions and intercellular communication with the control of cell growth, the cell cycle and, how the relationship is disrupted during carcinogenesis. Our interest in gap junctions as potential biomarkers of cancer and, more recently, the advent of new screening methodologies has expanded our efforts into broad proteomic screens for potential cancer biomarkers using mass spectrometry and large format antibody array technologies. We study potential biomarkers for ovarian, pancreas, colon and breast cancer. Our ongoing cell/molecular research involves the regulation of gap junction assembly and function. Gap junctions allow diffusion of small molecules (<1000 MW) between adjacent cells via matched cell-cell membrane channels. Vertebrate gap junctions are composed of proteins derived from the connexin gene family, and our results indicate that gap junction formation and degradation are highly regulated via protein kinases at various stages of the assembly process and the cell cycle. Current studies include determination of the cellular localization of different connexin phosphorylation events and the specific serine substrates that are phosphorylated within connexins in different tissues in response to insults such as skin wounding or cardiac hypoxia. Thus, we attempt to link the activation of specific kinases to phosphorylation on a particular residue within the connexin protein and to connexin function in tissue with a goal of rational drug design.

Short Research Description: 
Regulation of gap junctional communication, Cancer biomarker
Areas of Interest: 
Cancer Biology
Cell Signaling & Cell/Environment Interactions
Keywords: 
<p> Cell Biology, Cell Components, Cell Proliferation, Membranes, Proteins and Macromolecules, Tumors, cell differentiation, cell proliferation, communication, cell-to-cell membrane channels, embryonic development, gap junctions, heterotrimeric, phosphorylation, protein kinases, tumor suppressors</p>
Publications


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