lehigdon

Student Profile

First Name: 
Lauren
Last Name: 
Higdon
Primary Institution: 
UW
Department/Division: 
other
Department/Division: 
Immunology
MCB Entry Quarter: 
Autumn
MCB Entry Year: 
2009
Mail/Box #: 

358059

Address: 

Lab Information
Advisor: 
Lab Location: 
SLU 3.1
Lab Phone #: 
(206) 685-3746
Research
Research Summary: 

I study a subset of helper (CD4) T cells that undergo a process in which the T cell receptor (TCR) revises.  Normally TCRs form during T cell development as a result of gene rearrangement.  These T cells revise their TCRs to become tolerant to an endogenous super antigen. I am studying the phenotype of these cells to determine whether they are follicular helper T cells, which are the T cells involved in direct B cell - T cell interactions.  In addition, I am studying whether these B cell - T cell interactions are necessary for TCR revision to occur.

Areas of Interest: 
Microbiology, Infection & Immunity
Publications: 
21402911
Academic Information
TA/Out Reach
Class/Activity: 
Biol 200
Quarter: 
Autumn
Year: 
2010
Class/Activity: 
Biol 405
Quarter: 
Spring
Year: 
2011
Class/Activity: 
MCB Transcript Editor
Graduate School
Dissertation Title: 
Receptor revision in CD4 T cells is influenced by follicular helper T cell formation and germinal center interactions