Stamatatos, Leonidas

Faculty Profile

First Name: 
Leonidas
Last Name: 
Stamatatos
[field_fname-formatted] [field_lname-formatted]
Title: 
Member
Primary Institution: 
FHCRC
Department/Division: 
Vaccine and Infections Disease Institute
Department/Division: 
other
Mail/Box #: 

Office Location: 

FHCRC 358080/E5-110

Office Phone: 
206-667-2995
Research

Research Summary: 

The emphasis of the Stamatatos group’s work is to develop a safe and effective vaccine to combat the spread of HIV and to investigate how HIV infection leads to AIDS. Our team has two major areas of research: (a) to better understand how neutralizing antibodies against HIV are developed during natural HIV-infection, and (b) engineer immunogens that will elicit broadly neutralizing antibody responses against HIV. In particular, we are interested in: a) identifying immunological pathways that lead to the development of broadly neutralizing antibodies during natural HIV infection and exploit these pathways for vaccine-related purposes; b) design immunogens that active the precursors of those B cells that give produce broadly neutralizing antibodies; and c) develop prime-boost immunization regiments to guide the maturation of those B cells clones that produce broadly neutralizing antibodies. Our work encompasses the entire spectrum of basic to clinical vaccine research.

Short Research Description: 
HIV immunity
Areas of Interest: 
Microbiology, Infection & Immunity
Keywords: 
<p> HIV, humoral immunity, vaccine-development and evaluation</p>