The emphasis of the Stamatatos group’s work is to develop a safe and effective vaccine to combat the spread of HIV and to investigate how HIV infection leads to AIDS. Our team has two major areas of research: (a) to better understand how neutralizing antibodies against HIV are developed during natural HIV-infection, and (b) engineer immunogens that will elicit broadly neutralizing antibody responses against HIV. In particular, we are interested in: a) identifying immunological pathways that lead to the development of broadly neutralizing antibodies during natural HIV infection and exploit these pathways for vaccine-related purposes; b) design immunogens that active the precursors of those B cells that give produce broadly neutralizing antibodies; and c) develop prime-boost immunization regiments to guide the maturation of those B cells clones that produce broadly neutralizing antibodies. Our work encompasses the entire spectrum of basic to clinical vaccine research.
Copyright © 2003-2014 Molecular & Cellular Biology Program, University of Washington
Fred Hutchison Cancer Research Center | University of Washington
Institute for Systems Biology | Seattle Biomed