Wang, Liguo

Faculty Profile

First Name: 
Liguo
Last Name: 
Wang
Title: 
Assistant Professor
Primary Institution: 
UW
Department/Division: 
other
Department/Division: 
Biological Structure
E-Mail: 
Mail/Box #: 

University of Washington

Biological Structure
1959 NE Pacific St
Box 357420
Seattle, Washington 98195-7420

Office Location: 

G-519, Health Sciences Center

Office Phone: 
(206) 616-7894
Research

Research Summary: 

We are interested in probing the structures of membrane proteins and their complexes, and understanding the molecular basis of their biological functions. We have developed a novel and general method, called "random spherically constrained" (RSC) single-particle electron cryomicroscopy (cryo-EM), to study membrane protein structures in membrane environments. This method does not rely on crystallization, and it can be, in principle, applied to any membrane protein. This method not only preserves the membrane protein’s integrity and native conformation, but also enables access to biologically interesting states. The technique opens up a new way to study many important molecular machines of cellular membranes. It allows researchers to choose their targets based on the biological importance, not the possibility of forming crystals.

Short Research Description: 
Membrane protein structures by cryo-EM
Areas of Interest: 
Molecular Structure & Computational Biology
Keywords: 
<p> membrane protein, structure, cryo-electron microscopy, ion channels, protein function, reconstitution</p>
Publications


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