My lab has two projects, both employing C. elegans as a model system, and using genetics, biochemistry and imaging techniques.
Dense-core vesicles and G protein signaling
We are interested in the function of neuromodulators, molecules that regulate neuronal properties to control our moods, emotions and appetites. We study how neuromodulators are packaged into dense-core vesicles, how these vesicles are trafficked and released, and how cells respond to neuromodulatory signals. Using forward genetic screens, we have discovered new molecules involved in dense-core vesicle biogenesis and G protein signal transduction. Our goal is to understand how these molecules work at the cellular level.
Genetics of hybrid incompatibility
We are interested in identifying genes that lead to speciation events in C. elegans and related nematodes. In C. elegans, we are investigating the cellular mechanism of action of a novel selfish genetic element that consists of a sperm supplied toxin and its zygotically-acting antidote. In C. nouraguensis, we have discovered a genetic incompatibility that appears to be a conflict between the mitochondria of one strain and a nuclear locus of another. We are also screening for additional examples of hybrid incompatibility within Caenorhabditis species.
Copyright © 2003-2014 Molecular & Cellular Biology Program, University of Washington
Fred Hutch | University of Washington
Institute for Systems Biology (ISB)| Center for Infectious Disease Research