Ailion, Michael

Faculty Profile

First Name: 
Michael
Last Name: 
Ailion
[field_fname-formatted] [field_lname-formatted]
Title: 
Assistant Professor
Primary Institution: 
UW
Department/Division: 
other
Department/Division: 
Biochemistry
E-Mail: 
Mail/Box #: 

357350

Office Location: 

J341 HSB

Office Phone: 
206-685-0111
Research

Research Summary: 

My lab has two projects, both employing C. elegans as a model system, and using genetics, biochemistry and imaging techniques.

 

Dense-core vesicles and G protein signaling

We are interested in the function of neuromodulators, molecules that regulate neuronal properties to control our moods, emotions and appetites. We study how neuromodulators are packaged into dense-core vesicles, how these vesicles are trafficked and released, and how cells respond to neuromodulatory signals. Using forward genetic screens, we have discovered new molecules involved in dense-core vesicle biogenesis and G protein signal transduction. Our goal is to understand how these molecules work at the cellular level.

 

Genetics of hybrid incompatibility

We are interested in identifying genes that lead to speciation events in C. elegans and related nematodes. In C. elegans, we are investigating the cellular mechanism of action of a novel selfish genetic element that consists of a sperm supplied toxin and its zygotically-acting antidote. In C. nouraguensis, we have discovered a genetic incompatibility that appears to be a conflict between the mitochondria of one strain and a nuclear locus of another. We are also screening for additional examples of hybrid incompatibility within Caenorhabditis species.

Short Research Description: 
Mechanisms of neuromodulation; speciation genetics
Areas of Interest: 
Cell Signaling & Cell/Environment Interactions
Genetics, Genomics & Evolution
Neuroscience
Keywords: 
<p> C. elegans, neurobiology, genetics, speciation, neuromodulation, neurotransmission, dense-core vesicle</p>
Publications


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