Maizels, Nancy

Faculty Profile

First Name: 
Nancy
Last Name: 
Maizels
[field_fname-formatted] [field_lname-formatted]
Title: 
Professor
Primary Institution: 
UW
Department/Division: 
other
Department/Division: 
other
Mail/Box #: 

Box 357350

Office Location: 

H-474A Health Sciences Center

Office Phone: 
(206) 221-6876
Research

Research Summary: 

We study mechanisms of DNA repair and mutagenesis.  We have pioneered the use of DNA nicks as initiation sites for safer targeted gene correction in human cells, and we are currently developing novel strategies to make gene correction safer and more efficient.  We have developed new methods for measuring the covalent DNA-protein adducts that are generated by topoisomerases in the course of normal nuclear transactions, and we are applying these methods to understand adduct repair and to improve therapies targeted to DNA adduc.  We are also interested in the dynamic formation of G-quadruplex structures and their roles in cellular regulation.  Our research employs a variety of approaches, from biochemistry to somatic cell genetics to single-cell imaging — whatever is necessary to answer a particular question.

Short Research Description: 
genomic instability, gene therapy, cancer
Areas of Interest: 
Genetics, Genomics & Evolution
Keywords: 
<p> DNA repair, cancer, gene therapy, DNA mutagenesis, G4 DNA, G-quadruplex DNA, immune response, somatic hypermutation, gene conversion, homologous recombination, helicase, topoisomerase</p>
Publications


Related content

Student Profile
Course