McKnight, Stanley

Faculty Profile

First Name: 
Stanley
Last Name: 
McKnight
[field_fname-formatted] [field_lname-formatted]
Title: 
Professor
Primary Institution: 
UW
Department/Division: 
other
Department/Division: 
Pharmacology
Mail/Box #: 

Box 357750

Office Location: 

K540

Office Phone: 
(206) 616-4237
Research

Research Summary: 

We are using mouse embryonic stem cell approaches to introduce novel genetic mutations into the PKA regulatory system and investigating the major physiological functions of this signal transduction cascade. The mouse allows a full complement of genetic manipulations and in most instances provides a relevant model of human physiology, behavior, and disease. We use genetic techniques to produce tissue-specific activation or inactivation of PKA subunits and AKAPs (PKA scaffolding proteins). The lab has also developed a chemical-genetic approach that will allow drug dependent control of kinase activity in specific cell types in vivo.

Short Research Description: 
cAMP and PKA signaling in brain and heart
Areas of Interest: 
Cell Signaling & Cell/Environment Interactions
Neuroscience
Keywords: 
<p> brain, genetics, hormones, metabolism, pharmacology, proteins and macromolecules, transgenic animals, cardiac biology, cardiac disease, cardiovascular biology, developmentalbiology, mouse genetics, endocrinology, gene expression, gene regulation, genetic diseases, genetics, ion channels, mutagenesis, nervous system, neurobiology, neurons, reproductive biology, RNA, stem cells, signaling scaffolds, cAMP, PKA, AKAPs</p>
Publications


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