McKnight, Stanley

Faculty Profile

First Name: 
Stanley
Last Name: 
McKnight
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Title: 
Professor
Primary Institution: 
UW
Department/Division: 
other
Department/Division: 
Pharmacology
Mail/Box #: 

Box 357750

Office Location: 

K540

Office Phone: 
(206) 616-4237
Research

Research Summary: 

We are exploring the roles of PKA and localized signaling complexes in neural networks using mouse genetics and viral approaches.  The mouse allows a full complement of genetic manipulations and in most instances provides a relevant model of human physiology, behavior, and disease. We are focused on two areas of interest:  the involvement of cAMP/PKA in the regulation of energy metabolism and the role of localized PKA in the hippocampus.  In the hypothalamus, PKA activity modulates the sensitivity of neurons to leptin and controls feeding and energy expenditure.  In the hippocampus we have found that presynaptic PKA localized by an AKAP regulates synaptic plasticity in the dentate granule cells and controls contextual discrimination at a behavioral level.  We have developed techniques for isolating the translated mRNA population from specific subsets of neurons using ribosome tagging (RiboTag) and use this technique to examine changes in mRNA expression and translation as neurons respond to hormones and physiological stimuli.

Short Research Description: 
cAMP and PKA signaling in the brain
Areas of Interest: 
Cell Signaling & Cell/Environment Interactions
Gene Expression, Cell Cycle & Chromosome Biology
Neuroscience
Keywords: 
<p> brain, genetics, hormones, metabolism, pharmacology, proteins and macromolecules, transgenic animals, development, mouse genetics, endocrinology, gene expression, gene regulation, genetic diseases, genetics, ion channels, mutagenesis, nervous system, neurobiology, neurons, mRNA, stem cells, signaling scaffolds, cAMP, PKA, AKAPs</p>
Publications

Taking Students
Year: 
2014 - 2015

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