Merrikh, Houra

Faculty Profile

First Name: 
Houra
Last Name: 
Merrikh
Title: 
Assistant Professor
Primary Institution: 
UW
Department/Division: 
other
Department/Division: 
Microbiology
E-Mail: 
Mail/Box #: 

357735

Office Location: 

J-127A Health Sciences Building

Office Phone: 
(206) 221-1286
Research

Research Summary: 

The long-term goal of the Merrikh lab is to understand the mechanisms responsible for replication conflicts, their structural and functional consequences, and the mechanism of cellular response. Impediments to the replication machinery, including breaks, DNA binding proteins, and transcription, lead to conflicts that can result in genomic instability, mutagenesis, and a failure to segregate fully replicated genomes. We aim to identify and understand the mechanisms that are essential for avoidance, resolution and toleration of these conflicts. The lab employs molecular, genetic, biochemical, and cell biological approaches in the model system Bacillus subtilis (a Gram-positive bacterium) to understand how cells deal with obstacles encountered by replication. Replication conflicts occur in all life forms and the basic strategies used by cells to deal with these problems may be conserved across species. 

Short Research Description: 
Mechanisms of DNA replication and repair in bacteria
Areas of Interest: 
Gene Expression, Cell Cycle & Chromosome Biology
Genetics, Genomics & Evolution
Microbiology, Infection & Immunity
Keywords: 
<p> Replication, Bacillus, DNA damage, repair, recombination, genetics</p>
Publications


Related content

Student Profile