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Type VI secretion systems (T6SS) are complex molecular machines uses by bacteria to deliver effector proteins–often toxins–directly into other cells or their environments. The Mougous lab is interested in both understanding the mechanism of T6SS-mediated interbacterial interactions as well as the role they might play in the environment. I use a combination of population-level co-culture assays and single-cell time-lapse fluorescence microscopy methods to further characterize these interbacterial interactions using the HSI-I T6SS of Pseudomonas aeruginosa as a model.
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Fred Hutchison Cancer Research Center | University of Washington
Institute for Systems Biology | Seattle Biomed