Prlic, Martin

Faculty Profile

First Name: 
Martin
Last Name: 
Prlic
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Title: 
Assistant Member
Primary Institution: 
FHCRC
Department/Division: 
Vaccine and Infections Disease Institute
Department/Division: 
other
E-Mail: 
Mail/Box #: 

358080/E5-110

Office Location: 

Fred Hutchinson Cancer Research Center
Vaccine and Infectious Disease Division
1100 Eastlake Ave. E., E5-154
Seattle, WA 98109-2216

Office Phone: 
(206) 667-2216
Research

Research Summary: 

My laboratory studies immune responses following infection and vaccination, using in vivo (mouse) and in vitro (human) systems. Our goal is to understand how we can manipulate the immune system for therapeutic purposes. Current research directions include:

Regulating CD8 T Cell Responses
Many established vaccination programs depend on an efficient antibody response, but this classic approach has failed for current challenges such as malaria, HIV, and tuberculosis. CD8 T cells are key players in protecting against intracellular pathogens by eliminating infected cells and hence we believe a strong CD8 T cell response will be an integral part of a successful vaccine. 

Mucosal-associated invariant T (MAIT) cells
Human mucosal-associated invariant T (MAIT) cells are located at critical sites of pathogen entry, but their role in the immune response is poorly understood. Our goal is to understand their role in infections, chronic inflammatory responses and other inflammation-driven pathologies.

Using NK Cells against Opportunistic Infections
Hematopoietic cell transplantation (HCT) and solid organ transplantation (SOT) are important treatment options for several life-threatening diseases. Survival of patients undergoing these treatments has been markedly improved by advances in immunosuppression and conditioning. Infections, however, remain a significant risk for transplant recipients because immune responses are blunted to aid graft survival. My lab studies the role and therapeutic potential of NK cells in protecting against these opportunistic infections.

Short Research Description: 
Immune responses following infection and vaccination
Areas of Interest: 
Cancer Biology
Microbiology, Infection & Immunity
Keywords: 
<p> infection, vaccine, HIV, lymphocytes, T cell, NK cell, cell differentiation, cell fate decision, cancer, therapy</p>
Publications