Fred Hutchinson Cancer Research CenterVaccine and Infectious Disease Division1100 Eastlake Ave. E., E5-154Seattle, WA 98109-2216
My laboratory studies immune responses following infection and vaccination, using in vivo (mouse) and in vitro (human) systems. Our goal is to understand how we can manipulate the immune system for therapeutic purposes. Current research directions include:
Regulating CD8 T Cell Responses
Many established vaccination programs depend on an efficient antibody response, but this classic approach has failed for current challenges such as malaria, HIV, and tuberculosis. CD8 T cells are key players in protecting against intracellular pathogens by eliminating infected cells and hence we believe a strong CD8 T cell response will be an integral part of a successful vaccine.
Mucosal-associated invariant T (MAIT) cells
Human mucosal-associated invariant T (MAIT) cells are located at critical sites of pathogen entry, but their role in the immune response is poorly understood. Our goal is to understand their role in infections, chronic inflammatory responses and other inflammation-driven pathologies.
Using NK Cells against Opportunistic Infections
Hematopoietic cell transplantation (HCT) and solid organ transplantation (SOT) are important treatment options for several life-threatening diseases. Survival of patients undergoing these treatments has been markedly improved by advances in immunosuppression and conditioning. Infections, however, remain a significant risk for transplant recipients because immune responses are blunted to aid graft survival. My lab studies the role and therapeutic potential of NK cells in protecting against these opportunistic infections.
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Fred Hutch | University of Washington
Institute for Systems Biology (ISB)| Center for Infectious Disease Research