Nathanson, Neil

Faculty Profile

First Name: 
Neil
Last Name: 
Nathanson
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Title: 
Professor
Primary Institution: 
UW
Department/Division: 
other
Department/Division: 
Pharmacology
Mail/Box #: 

Box 357750

Office Location: 

K536A

Office Phone: 
(206) 543-9457
Research

Research Summary: 

Our laboratory is interested in the regulation of and mechanisms responsible for signal transduction in excitable cells. We have had a long-standing interest in the muscarinic acetylcholine receptors (mAChR), which comprise a family of related receptor proteins which are the products of distinct genes. Muscarinic receptors can regulate the activity of enzymes involved in intracellular second messenger pathways, such as adenylyl and guanylyl cyclases, phospholipase C, phosphodiesterases, and protein kinases, and can also regulate the function of ion channels. The mAChR gene family produces these effects by interacting with the members of a second gene family, the GTP-binding coupling proteins (G-proteins), which are required for receptor function. We are using a combination of molecular genetic, immunological, biochemical, physiological, and behavioral studies to study the regulation of expression and mechanisms of action of the mAChR and G-proteins in the nervous system.

Short Research Description: 
signal transduction in excitable cells
Areas of Interest: 
Cell Signaling & Cell/Environment Interactions
Neuroscience
Keywords: 
<p> signal transduction, cell membranes, protein targeting, nervous system, pharmacology, proteins and macromolecules, receptors, brain, cell biology, cell differentiation, cell growth, receptor, cytokine, neurokine, developmental neurobiology,seizures, neurogenesis, neurological disease, gene expression, gene regulation, growth factor receptors, growth factors, nervous system, neurobiology, neuroscience, peripheral nervous system, synapse, synapses, transmitters, neurotransmitter, knockout, gene targeting, developmental biology, muscarinic, neurotransmitter receptor, celll membrane, neuron, nerve cell, heart</p>
Publications


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