Research in my laboratory focuses on three matrix metalloproteinases-matrilysin (MMP-7), stromelysin-2 (MMP-10), and epilysin (MMP-28) - and how these secreted enzymes function in defense and repair. We are primarily interested in the innate immune functions conferred by the epithelium, including defense against microorganisms, wound repair and differentiation, and recruitment of inflammatory cells, and how MMPs regulate aspects of macrophage function and activation. We have determined that these three MMPs serve distinct, non-overlaping functions in several distinct processes of innate immunity. Our goal is to understand mechanism; that is, to identify the physiologic protein substrates of individual MMPs whose cleavage regulates specific processes, such as neutrophil activation, cell migration, etc.
Copyright © 2003-2014 Molecular & Cellular Biology Program, University of Washington
Fred Hutchison Cancer Research Center | University of Washington
Institute for Systems Biology | Seattle Biomed