Our laboratory is studying the genetic mechanisms of aging, with a special interest in the process of accelerated aging (progeroid syndromes). In the past, we identified two classes of genes that are responsible for the progeroid syndromes; a DNA repair protein (WRN helicase) and nuclear structural proteins (lamins). Current research projects include (1) molecular and cellular mechanisms of accelerated aging involving telomere, lamin and the WRN helicase; and (2) identification of new progeroid syndrome genes. Other ongoing studies include the patient registry of Werner syndrome (“Progeria of Adult”) and genetic risk factors of common age-related disorders.
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Fred Hutchison Cancer Research Center | University of Washington
Institute for Systems Biology | Seattle Biomed