Our laboratory is studying the genetic mechanisms of aging, with a special interest in the process of accelerated aging (progeroid syndromes). In the past, we identified two classes of genes that are responsible for the progeroid syndromes; a DNA repair protein (WRN helicase) and nuclear structural proteins (lamins). Current research projects include (1) molecular and cellular mechanisms of accelerated aging involving telomere, lamin and the WRN helicase; and (2) identification of new progeroid syndrome genes. Other ongoing studies include the patient registry of Werner syndrome (“Progeria of Adult”) and genetic risk factors of common age-related disorders.
Copyright © 2003-2014 Molecular & Cellular Biology Program, University of Washington
Fred Hutch | University of Washington
Institute for Systems Biology (ISB)| Center for Infectious Disease Research