Oshima, Junko

Faculty Profile

First Name: 
Junko
Last Name: 
Oshima
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Title: 
Research Professor
Primary Institution: 
UW
Department/Division: 
other
Department/Division: 
Pathology
Mail/Box #: 

357470

Office Location: 

K543B

Office Phone: 
(206) 616-4227
Alternate Phone: 
(206) 543-5088
Research

Research Summary: 

Our laboratory is studying the genetic mechanisms of aging, with a special interest in the process of accelerated aging (progeroid syndromes). In the past, we identified two classes of genes that are responsible for the progeroid syndromes; a DNA repair protein (WRN helicase) and nuclear structural proteins (lamins). Current research projects include (1) molecular and cellular mechanisms of accelerated aging involving telomere, lamin and the WRN helicase; and (2) identification of new progeroid syndrome genes. Other ongoing studies include the patient registry of Werner syndrome (“Progeria of Adult”) and genetic risk factors of common age-related disorders.

Short Research Description: 
Human Aging and Progeroid Syndromes
Areas of Interest: 
Cancer Biology
Genetics, Genomics & Evolution
Keywords: 
<p> Biotechnology, Cardiovascular Biology, Cardiovascular Physiology, Gene Expression, Gene Regulation, Gerontology, Medical Genetics, Pathology</p>
Publications