My lab studies natural genetic variation of aging and reproduction. Most of our research is focused on the fruit fly, but we also have ongoing studies on aging in marmosets and dogs. We use a diversity of approaches in our lab, including molecular and quantitative genetics, evolutionary theory, and systems biology methods to construct and analyze genetic and metabolomic networks. Among the current projects in the lab are 1) a study on the role that insulin signaling plays in determining how age affects mate attractiveness and mate preference; 2) the use of metabolomic profiling to identify novel aging-associated pathways; 3) identification of natural genetic modifiers of neurodegenerative disease in Drosophila; 4) studies on the molecular basis of sex differences in longevity; and 5) developing the fly as a model for pharmacogenomic studies.
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Fred Hutchison Cancer Research Center | University of Washington
Institute for Systems Biology | Seattle Biomed