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Molecular insight into the processes that underlie host:virus interactions can be gained by evaluating the genetic history of genes evolving under conflict. In this way, evolutionary signatures rationalize novel perspectives into host:virus interactions. The Malik Lab uses this approach to characterize the molecular evolution of host restriction factors, which we predict will lead to unique perspectives into the molecular mechanisms that afford intrinsic and innate immunity against viral pathogens.
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Fred Hutch | University of Washington
Institute for Systems Biology (ISB)| Center for Infectious Disease Research