Brent, Roger

Faculty Profile

First Name: 
Roger
Last Name: 
Brent
Title: 
Member
Primary Institution: 
FHCRC
Department/Division: 
Basic Sciences
Department/Division: 
Genome Sciences
E-Mail: 
Mail/Box #: 

Box 358080/A2-025

Office Location: 

2nd floor, Weintraub Building, FHCRC

Office Phone: 
206-667-1482
Research

Research Summary: 

 

The lab studies how living cells sense, represent, transmit, and act upon information to make decisions about their future states. Current studies concern a prototypic cell signaling system in yeast and has begun to expand to cell signaling systems. operating in multicellular organisms.  Much work concerns cell-to-cell variation in the operation of these systems in single cells, and study of the peristent, heritable physiological states defined by the extremes of this variation.  Experimental work relies on careful attention to development of accurate quantitative means to measure relevant molecular events and frequnently proceedes in concert with computational efforts to understand limits and uncertainties in the measurements. Work requires continual development and refinement of experimental and computational methods, many of which find application to other biological problems. Continued study should reveal hitherto undetected signaling events needed for metazoan development and somatic maintenance.  Continuing study of the genetic and physiological control of intracellular signals and the information they carry should continue to reveal additional mechanisms for cellular and organismic decision making. It should also suggest modalities for experimental manipulations and therapeutic interventions. 

The lab includes, experimentally, a social science component at the Center for Biological Futures, a two-year pilot project that aims to bring together biologists with scholars in the social sciences and humanities, including anthropologists and philosophers, to better understand how biological knowledge and capability are shaping human affairs in the 21st century. This project includes a significant collaboration with investigators at the University of Washington, in the project Biological Futures in a Globalized World.

Short Research Description: 
Quantitative function of signailng systems in single cells
Areas of Interest: 
Genetics, Genomics & Evolution
Publications