Strong, Roland

Faculty Profile

First Name: 
Roland
Last Name: 
Strong
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Title: 
Member
Primary Institution: 
FHCRC
Department/Division: 
Basic Sciences
Department/Division: 
other
E-Mail: 
Mail/Box #: 

A3-025

Office Location: 

B3-163 Weintraub

Office Phone: 
(206) 667-5587
Research

Research Summary: 

The research focus of the laboratory is structural molecular immunology, vaccinology and translational biophysics: using biophysical approaches to study NK and T cell receptors, understand immunorecognition of siderophores, further HIV vaccine development and engineer targeted immunotherapeutics to improve the diagnosis and treatment of cancer and diseases of the kidney.  Current projects include: (1) understanding the role siderocalins (ferric siderophore binding proteins of the innate immune system) play in cancer and kidney disease while leveraging their properties for engineering novel functionalities into therapeutics; (2) understanding the molecular mechanisms and ontogeny of broadly-neutralizing, anti-HIV antibodies; (3) engineering  receptor-specific reagents for managing graft vs. host disease as a sequela of hematopoietic stem cell transplantation; (4) engineering antibodies into optimized therapeutic and diagnostic reagents.  Current techniques used include x-ray crystallography, SPR/Biacore, ITC, AUC, CD and fluorescence spectroscopy, cell-based assays, and protein expression using the Daedalus platform.

Short Research Description: 
structural molecular immunology
Areas of Interest: 
Microbiology, Infection & Immunity
Molecular Structure & Computational Biology
Keywords: 
<p> structural immunology, structural molecular biology, x-ray crystallography, surface plasmon resonance, NK cells, T cells, immunoreceptors, siderophores, HIV, AIDS, antibodies, vaccines</p>
Publications


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