rtmoon

Randall Moon studies the highly conserved Wnt signal transduction pathways. Wnts are secreted ligands that activate receptor-mediated pathways that regulate cell proliferation, cell fate, and cell behavior in development, and stem and progenitor cells in adults. His first goal is to identify the roles of Wnt signaling at the level of the organism, with a focus on regenerative processes in adults. His second goal is to elucidate the mechanisms by which Wnts signal. His third goal is to understand how Wnt signaling is linked to diseases, and to identify candidate therapies. Approaches used range from studying human embryonic stem cells,to genome-wide siRNA screens, to small molecule screens, to proteomics.