Biggins, Sue

Faculty Profile

First Name: 
Sue
Last Name: 
Biggins
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Title: 
Member
Primary Institution: 
FHCRC
Department/Division: 
Basic Sciences
Department/Division: 
other
E-Mail: 
Mail/Box #: 

A2-168

Office Location: 

A2-155

Office Phone: 
(206) 667-1351
Alternate Phone: 
(206) 667-5766
Research

Research Summary: 

How do cells faithfully inherit a complete set of chromosomes during every cell division? We are studying the mechanisms that govern chromosome segregation during the cell cycle. Defects in this process are a hallmark of many cancers and birth defects.  Our focus is on the kinetochore, the protein complex that binds to microtubules. We are taking an interdisciplinary approach to understanding how cells assemble kinetochores and how the kinetochores mediate attachments to microtubules.  We also work on the spindle checkpoint, a signal transduction system that halts the cell cycle when there are errors in kinetochore-microtubule attachments.   

Short Research Description: 
Regulation of Chromosome Segregation
Areas of Interest: 
Gene Expression, Cell Cycle & Chromosome Biology
Keywords: 
<p> Cell Biology, Genetics, Mitosis, Cell Cycle, Chromosomes, Genetics, Kinetochores, Yeast, Aurora kinase</p>
Publications

Taking Students
Year: 
2014 - 2015

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