Brockerhoff, Susan

Faculty Profile

Submitted by Brockerhoff, Susan on Fri, 10/08/2010 - 6:25pm

First Name:

Susan

Last Name:

Brockerhoff

Title:

Associate Professor

Primary Institution:

Department/Division:

other

Department/Division:

Biochemistry

E-Mail:

sbrocker@u.washington.edu

Mail/Box #:

357350

Office Location:

J-583 (Office) Health Sciences Bldg, J579 (Lab)

Office Phone:

(206) 616-9464

Alternate Phone:

(206) 616-8249

Lab Website:

http://faculty.washington.edu/sbrocker/wordpress/

Research

Research Summary:

The overall goal of research in my laboratory is to understand the biology of the cone photoreceptor and apply this information to dissecting the molecular basis of human retinal disease. We use zebrafish as our model system because they have an abundance of cone photoreceptors and because biological problems can be tackled in zebrafish using many different experimental approaches.

Over several years we have identified zebrafish mutants that have impaired vision because of defects in cone photoreceptor structure/function. Mutations we have characterized previously alter different aspects of cone photoreceptor biology such as, phototransduction (nof), synaptic transmission (nrc), metabolism (noa), and cell viability (pob, pde6c). We have several projects in the lab involving characterizing and identifying mutants. Our current emphasis is on understanding mechanisms of cell death and analyzing the role of phosphoinositides in protein trafficking.

departmental lab page: http://depts.washington.edu/biowww/faculty/brockerhoff-susan/

Short Research Description:

Study of cone photoreceptor biology.

Areas of Interest:

Cell Signaling & Cell/Environment Interactions

Neuroscience

Keywords:

<p> Biochemistry, Blindness, Cell Biology, Photoreceptor Diseases, Fish and Fisheries, Neuroscience, Ophthalmology, Synaptic Transmission, Vertebrate Physiology, Vision</p>

Publications

PubMed Search Term:

brockerhoff se