Brockerhoff, Susan

Faculty Profile

First Name: 
Susan
Last Name: 
Brockerhoff
[field_fname-formatted] [field_lname-formatted]
Title: 
Professor
Primary Institution: 
UW
Department/Division: 
other
Department/Division: 
Biochemistry
E-Mail: 
Mail/Box #: 

357350

Office Location: 

S261 (Office) SLU E building, S240 (Lab)

Office Phone: 
(206) 616-9464
Alternate Phone: 
(206) 616-8249
Research

Research Summary: 

The overall goal of research in my laboratory is to understand the biology of the cone photoreceptor and apply this information to dissecting the molecular basis of human retinal disease. We use zebrafish as our model system because they have an abundance of cone photoreceptors and because biological problems can be tackled in zebrafish using many different experimental approaches.

Over several years we have identified zebrafish mutants that have impaired vision because of defects in cone photoreceptor structure/function. Mutations we have characterized previously alter different aspects of  cone photoreceptor biology such as, phototransduction (nof), synaptic transmission (nrc), metabolism (noa), and cell viability (pob, pde6c).  Our current emphasis is on understanding mechanisms of metabolic regulation and the dysregulation that occurs during photoreceptor cell death.  We also are examining the role of phosphoinositides in photoreceptor trafficking.

departmental lab page: http://depts.washington.edu/biowww/faculty/brockerhoff-susan/

Short Research Description: 
Study of cone photoreceptor biology.
Areas of Interest: 
Cell Signaling & Cell/Environment Interactions
Neuroscience
Keywords: 
<p> Biochemistry, Blindness, Cell Biology, Photoreceptor Diseases, Fish and Fisheries, Neuroscience, Ophthalmology, Synaptic Transmission, Vertebrate Physiology, Vision</p>
Publications

Taking Students
Year: 
2013 - 2017