S261 (Office) SLU E building, S240 (Lab)
The overall goal of research in my laboratory is to understand the biology of the cone photoreceptor and apply this information to dissecting the molecular basis of human retinal disease. We use zebrafish as our model system because they have an abundance of cone photoreceptors and because biological problems can be tackled in zebrafish using many different experimental approaches.
Over several years we have identified zebrafish mutants that have impaired vision because of defects in cone photoreceptor structure/function. Mutations we have characterized previously alter different aspects of cone photoreceptor biology such as, phototransduction (nof), synaptic transmission (nrc), metabolism (noa), and cell viability (pob, pde6c). Our current emphasis is on understanding mechanisms of metabolic regulation and the dysregulation that occurs during photoreceptor cell death. We also are examining the role of phosphoinositides in photoreceptor trafficking.
departmental lab page: http://depts.washington.edu/biowww/faculty/brockerhoff-susan/
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Fred Hutchison Cancer Research Center | University of Washington
Institute for Systems Biology | Seattle Biomed