Our lab is interested in the dynamic properties of mitochondria and how these affect mitochondrial function and the integration of mitochondrial dynamics with other cellular processes. Mitochondrial dysfunction is implicated in a wide array of human diseases including neurdegeneration, cardiac disease, obesity, diabetes and cancer. Mitochondria form an extensive tubular network in cells that is modified and regulated by membrane fusion, division, organelle transport and tethering events. These dynamic properties are essential for mitochondrial function and have also been integrated with other cellular pathways including cell cycle progression and cell death. We are interested in the machines that mediate membrane fusion and the various forms of regulation that exist in mammalian cells.
Copyright © 2003-2013 Molecular & Cellular Biology Program, University of Washington
Fred Hutchison Cancer Research Center | University of Washington
Institute for Systems Biology | Seattle Biomed