slnewman

Student Profile

First Name: 
Shannon
Last Name: 
Newman
[field_fname-formatted] [field_lname-formatted]
Primary Institution: 
UW
Department/Division: 
other
Department/Division: 
Microbiology
MCB Entry Quarter: 
Autumn
MCB Entry Year: 
2011
E-Mail: 
Mail/Box #: 

357735

Phone: 
(630) 308-5002
Lab Information
Advisor: 
Lab Location: 
K-455
Lab Phone #: 
(206) 616-4282
Research
Research Summary: 

I work in the lab of Professor Ferric Fang to investigate the mechanisms by which virulence genes become activated in the bacterial pathogen Salmonella enterica. We propose that horizontally acquired genes become integrated into the host regulatory networks in Salmonella, a process we have termed xenogeneic silencing. Incorporated genes are typically silenced to reduce detrimental effects but can effectively countersilenced, or "turned-on", under appropriate environmental conditions. Many of these newly regulated genes govern Salmonella virulence properties. My goal seeks to understand some of these regulatory processes, specifically how the alternative sigma factor, sigmaS, is able to serve as a countersilencer during progression into bacterial stationary phase. To determine the mechanism by which this occurs, I will perform in vitro transcription assays as well as a number of biochemical assays, including DNaseI, KMnO4, and UV laser footprinting analyses.

Areas of Interest: 
Cancer Biology
Gene Expression, Cell Cycle & Chromosome Biology
Genetics, Genomics & Evolution
Academic Information
TA/Out Reach
Class/Activity: 
Biology 355
Quarter: 
Winter
Year: 
2013
Class/Activity: 
SEP
Quarter: 
Summer
Year: 
2013