Tsukiyama, Toshio

Faculty Profile

First Name: 
Toshio
Last Name: 
Tsukiyama
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Title: 
Member
Primary Institution: 
FHCRC
Department/Division: 
Basic Sciences
Department/Division: 
other
E-Mail: 
Mail/Box #: 

A1-162

Office Location: 

Fred Hutchinson Cancer Research Center
1100 Fairview Ave. N., Rm. A1-169
Seattle, WA 98109

Office Phone: 
(206) 667-4996
Research

Research Summary: 

We are interested in understanding how chromatin structure is regulated in vivo. In eukaryotic cells, DNA is packaged into chromatin. This allows compact storage of the genome, but limits the access of DNA binding proteins to their targets. Therefore, chromatin structure strongly influences all the processes that rely on protein-DNA interactions, such as transcription, DNA replication, repair and recombination. One of the major challenges in studying chromatin regulation is to elucidate how chromatin regulation affects such a wide variety of processes in the context of important biological contexts, such as cell cycle control and cell differentiation.  We are particularly interested in understanding how chromatin regulation affects cell cycle control. We are using the budding yeast Saccharomyces cerevisiae as a model organism, because functions of genes can be studied most readily by genetic and biochemical approaches in this system but easily applied to multicellular eukaryotes.

Short Research Description: 
Chromatin regulation
Areas of Interest: 
Gene Expression, Cell Cycle & Chromosome Biology
Keywords: 
<p> chromatin, biochemistry, genetics, DNA replication, transcription, non-coding RNA</p>
Publications

Taking Students
Year: 
2013 - 2014

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