Vieira, Jeffrey

Faculty Profile

First Name: 
Jeffrey
Last Name: 
Vieira
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Title: 
Research Associate Professor
Primary Institution: 
UW
Department/Division: 
other
Department/Division: 
other
Mail/Box #: 

358070

Office Location: 

Rosen Building, Room 120, 960 Republican St., Seattle, 98109

Office Phone: 
(206) 732-6107
Research

Research Summary: 

The laboratory primarily works on the molecular biology of Kaposi's sarcoma-associated herpesvirus (KSHV), the eighth human herpesvirus (HHV-8). KSHV is involved in Kaposi's sarcoma, primary infusion lymphoma, and some forms of multicentric Castleman's disease. All herpesviruses can alternate between latent and lytic replication, which allows the permanent infection of the host, and is a vital aspect of the pathogenesis of these viruses. One area of research for the lab is the understanding of viral and cellular factors important for the activation of lytic genes, and the activation of lytic replication during the development of epithelium. We employ a recombinant KSHV that allow the distinction between latent and lytic gene expression by the expression of different fluorescent proteins. The lab also works on KSHV gene functioning and immunology.

Short Research Description: 
molecular biology of Kaposi's sarcoma-associated herpesvirus
Areas of Interest: 
Microbiology, Infection & Immunity
Keywords: 
<p> virology, herpesvirus, Kaposi&#39;s sarcoma, KSHV, HHV-8, latency, reactivation, gene expression, chromatin, pathogenesis, viral lytic replication, in vitro models of epithelium, fluorescent proteins, recombinant virus, tissue culture, epithelial differentiation</p>
Publications


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