I am investigating the contribution of electrical synapses in modulation between neural circuits. Modulation of circuits is important as it plays a key role in altering thought and behavior in response to learned experiences. One of the open questions in systems neuroscience is how the behavior of one circuit affects that of another. One possible mechanism of modulation is through electrical synapses. Electrical synapses are points of physical contact between neurons that allow ions and small molecules to pass between the cytoplasm of the connected cells. I am using a synapse engineering approach in the nematode C. elegans to investigate how these gap junctions contribute to cross-circuit modulation.
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Fred Hutchison Cancer Research Center | University of Washington
Institute for Systems Biology | Seattle Biomed